Antioxidant Phytochemical Screening and Antimicrobial Activity of Ficus exasperata Against Pathogens in Nigeria

Antioxidant Phytochemical Screening and Antimicrobial Activity of Ficus exasperata Against Pathogens in Nigeria

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  • February 8, 2019
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Background and Objective: Development of microbial resistance to drugs has led scientists to study the role of natural substances such as medicinal plants with antimicrobial and antioxidant activity compared to synthetic drugs. Aim of present study was to evaluate antimicrobial and antioxidant activities of Ficus exasperata leaves against selected human pathogens and also screen medicinal plant for phytochemical activity in comparison to the synthetic drugs. Materials and Methods: Fic u s e x a s p e r a t a was screened for phytochemicals by standard methods, it was also observed for their antimicrobial activity by agar well diffusion methods. Antioxidant activities were assessed on  the  basis  of  the  scavenging  effect  of the 2, 2-dipheny-1-pircryl hydrazyl (DDPH) free radicals activity. Results: Phytochemical  screening showed presence of steroids, tannins, saponins, anthocyanins, phenols, anthraquinones, flavonoids, terpenoids and alkaloids. Highest concentrations of extracts resulted in highest antimicrobial activity. Ethyl acetate extracts showed highest antimicrobial activity against pathogens which was followed by methanolic extract . Lowest minimum inhibitory concentration was also shown by ethyl acetate, followed by methanol. As concentration of plant extract increased, antioxidant activity also increased. Ethyl acetate was able to show highest activity of antioxidants compared to other solvents. Conclusion: Based on broad spectrum activity of F. exasperata  extracts  as revealed by this research supports its usage as natural antimicrobial and antioxidant compared to the synthetic drugs.

Key words: Ficus exasperata , phytochemicals, microbial resistance, human pathogens, natural antimicrobial, antioxidant activities

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